Reducing wound scars by activating immune system by hydrogels

The MAP (microporous annealed particle) gel which is a promising wound healing support has been modified to trigger or start a particular immune response which can treat

  • Burns
  • Cuts
  • Diabetic ulcers
  • Scarred skin

Tatiana Segura a biomedical engineer from Duke University said that by activating the immune system, the balance of the wound healing can be tilted from tissue destruction and scar formation to repairing tissue and regenerating skin.

Don Griffin another biomedical engineer from University of Virginia said that MAP gel loses porosity when the wound started healing which limits the growth of tissue leaving scars due to early closure of skin pores.

While working with mouse models, by  increasing lifetime of scaffold ( materials engineered to cause desirable  cellular interactions to form new functional tissues) through adaptive immune system using different types of cells like antibodies and macrophages which shows better removal of hydrogel traces as well as repairing skin which looked like original skin including sweat glands and hair follicles.

Human trials are yet to be done in this regard and if successful then it will be a great achievement in the field of biomedical engineering.

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